Scientists target bacteria ‘quorum sensing’ as route to antibacterial therapies

R&D Mag – During quorum sensing, bacteria produce, detect, and exchange signaling molecules known as autoinducers. This process is crucial to disease development because it ultimately controls the way that bacteria express “virulence factors“—the molecules that enable the bacteria to colonize a host, evade and compromise the host’s immune response, exit and enter cells, and obtain nutrients.

By studying how to inhibit quorum sensing, scientists may be able create antibacterial pharmaceuticals for a variety of ailments.

Recently, in part due to work performed at NSLS, researchers from Princeton University and the Howard Hughes Medical Institute learned how to block a quorum-sensing mechanism in the bacteria. more>


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