Monitoring of singlet oxygen in individual cells with InGaAs camera


R&D – Singlet oxygen, the first excited state of molecular oxygen, is a highly reactive species that plays an important role in a wide range of biological processes, including cell signaling, immune response, macromolecule degradation, and elimination of neoplastic tissue during photodynamic therapy. Often, a photosensitizing process is employed to produce singlet oxygen from ground state oxygen.

The researchers at Charles Univ. utilized two detection channels (VIS and NIR) to perform real-time imaging of the very weak near-infrared phosphorescence of singlet oxygen and photosensitizer simultaneously with visible fluorescence of the photosensitizer. Their new experimental setup enables acquisition of spectral images based on singlet oxygen and photosensitizer luminescence from individual cells. more> http://tinyurl.com/kuhbuzc

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